1161 UV irradiation modulates appetite and body weight through upregulating norepinephrine in mice

Ultraviolet (UV) irradiation to the skin downregulates lipid synthesis and adipokine production in subcutaneous fat. Recent evidence also suggests that UV exposure limits body weight gain obesity models. However, it is still unclear how chronic modulates energy metabolism of whole body. High fat- or normal diet-fed female C57BL/6 mice were treated with sham for 12 weeks. stimulated food intake but prevented gain. Leptin, an appetite-suppressing hormone, was significantly reduced serum, skin, inguinal fat high UV-irradiated mice. Besides, promoted orexigenic pathway involving neuropeptide Y agouti-related peptide hypothalamus. Mice showed browning white adipose tissues increased thermogenesis without physical activity. Notably, liquid chromatography/mass spectrometer analyses revealed norepinephrine among most neurotransmitters mice, downregulation by dopamine β-hydroxylase inhibitor nepicastat reversed effects on weight. In conclusion, induces NE release resulting stimulating due anorexigenic hormone leptin, preventing through elevation expenditure.